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Description

The peptide's mechanism involves disrupting the FOXO4-p53 interaction specifically in replication-stressed senescent chondrocytes, triggering selective apoptosis while preserving healthy proliferative cells needed for cartilage formation

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Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406) 39(4):285-294, 2021

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